Tom Clancy's Rainbow Six 3 - I have never had so much fun with a video game! Nathanga got it for me this Christmas and i have played it every day since. From the planning to the execution (including all the heads up display),
RB6 offers more choices, great live play, realistic play and graphics.
Missions vary but are around the basic idea that you are a member of an elite anti-terrorism squad and you get to blow away bad guys, disarm bombs, rescue hostages, and basically save the free world every day.
The first time you get killed is unbelievable - I never saw it coming - I was just dead! But you get to take control of other team members until they're all dead then try again.
I use a tracball so shooting is really easy but if you use a wheelmouse you can open doors better. I just throw open and go in blasting so i don't need to be that fluid but make your own choices. My advice is to ad a third team to the first level and play as that team (single member) then follow the other teams in until you get used to moving.
After a few runs you get the basics but you will keep learning for a long time with this baby!
Play and have fun - If you want to help with Seachele's Handcycle